Seven matches were played across the day, with Crystal Palace producing the comeback of the afternoon at Fulham, Manchester City maintaining their 100 per cent start and Newcastle United rescuing a point from a difficult position against Bournemouth.
The American sisters were beaten by 14th seeds Maya Joint and Chan Hao-Ching 6-3, 6-7 (6-8), 7-6 (10-7) after three hours and two minutes of gripping tennis.
Troy Parrott came off the bench to score the only goal as Real Betis defeated Madrid 1-0, handing Mourinho his first defeat since returning to the Real Madrid dugout.
The development could revive hopes of seeing the two British heavyweights finally meet on home soil after Madison Square Garden in New York had emerged as a leading alternative for the event.
The German, seeded first at a Grand Slam for the first time in his career, needed four hours and 33 minutes to finally put away Halys in a contest that stretched into the early hours of Friday morning.
Clubs spent more than $9.89 billion on international transfer fees during the 2026 mid-year window, according to FIFA, setting a new record for a period that has traditionally been dominated by the biggest leagues and wealthiest clubs.